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The aim of this course is to provide participants with an overview of quantitative genetics, with specific application to shape analysis and decomposition of phenotypic variation into components of genetic and environmental variation. The basic theoretical concepts of resemblance between relatives, heritability, estimates of selection, and geometric morphometrics will be introduced. Practical lessons will enable participants to learn to use user-friendly (and not so user-friendly) software packages to estimate heritability, phenotypic and genetic variance covariance matrices, response to hypothetical selection, actual selection and QTL mapping. Participants are encouraged to bring their own data for analysis and discussion in the course. Morphometric data involves any kind of quantitative shape data collected on individuals, such as linear measurements and/or 2D or 3D landmark coordinates. Pedigree files usually consist of text files with a list of three columns (individual ID, father ID, mother ID). Specific details about formatting these files will be provided during the practical lessons.
Dr. Neus Martínez-Abadías
(Centre for Genomic Regulation, Spain).
Dr. Nicolas Navarro
(École Pratique des Hautes Études, France).
Dr. Soledad De Esteban-Trivigno
(Transmitting Science, Spain).
Graduate or postgraduate degree in Life or Earth Sciences, basic knowledge of statistics and personal computers. Knowledge of Genetics and Geometric Morphometrics. All participants must bring their own personal laptop.
We would like to encourage participants to bring along their own morphometrics data and pedigree / quantitative genetic information.
- Overview of Quantitative Genetics.
- Quantitative genetics of shape on a multivariate framework.
- Shape and selection.
- QTL mapping of multivariate traits.
- Klingenberg CP, Leamy LJ, Routman , EJ, Cheverud, JM (2001) Genetic architecture of mandible shape in mice: Effects of quantitative trait loci analyzed by geometric morphometrics. Genetics, 157: 785-802.
- Mcguigan K (2006) Studying phenotypic evolution using multivariate quantitative genetics. Molecular Ecology, 15: 883-896.
- Navarro N, Klingenberg CP (2007) Mapping multiple QTLs of geometric shape of the mouse mandible, in S. Barber, P.D. Baxter and K.V. Mardia (eds), Systems Biology and Statistical Bioinformatics, p. 125-128. Leeds, Leeds University Press.
- Klingenberg CP (2010) Evolution and development of shape: Integrating quantitative approaches. Nature Reviews Genetics, 11: 623-635.
- Martínez-Abadías N, Esparza M, Sjøvold T, González-José R, Santos M, Hernández M (2009) Heritability of human cranial dimensions: Comparing the evolvability of different cranial regions. Journal of Anatomy, 214: 19-35.
- Martínez-Abadías N, Esparza M, Sjøvold T, González-José R, Santos M, Hernández M, Klingenberg CP (2012) Pervasive genetic integration directs the evolution of human skull shape. Evolution, 66: 1010-23.
Classical books on Quantitative Genetics:
- Falconer DS and Mackay TFC (1996) Introduction to quantitative genetics, Essex: Longman Group, Ltd.
- Roff DA (1997) Evolutionary quantitative genetics, New York: Chapman & Hall.
- Lynch M and Walsh B (1998) Genetics analysis of quantitative traits, Sunderland, Massachusetts: Sinauer Associates.
For further information contact: firstname.lastname@example.org.
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