The aim of this course is to provide participants with an overview of quantitative genetics, with specific application to shape analysis and decomposition of phenotypic variation into components of genetic and environmental variation.
The basic theoretical concepts of resemblance between relatives, heritability, estimates of selection, and geometric morphometrics will be introduced. Practical lessons will enable participants to learn to use user-friendly (and not so user-friendly) software packages to estimate heritability, phenotypic and genetic variance covariance matrices, response to hypothetical selection, actual selection and QTL mapping.
Participants are encouraged to bring their own data for analysis and discussion in the course. Morphometric data involves any kind of quantitative shape data collected on individuals, such as linear measurements and/or 2D or 3D landmark coordinates. Pedigree files usually consist of text files with a list of three columns (individual ID, father ID, mother ID). Specific details about formatting these files will be provided during the practical lessons.
- Klingenberg CP, Leamy LJ, Routman , EJ, Cheverud, JM (2001) Genetic architecture of mandible shape in mice: Effects of quantitative trait loci analyzed by geometric morphometrics. Genetics, 157: 785-802.
- Mcguigan K (2006) Studying phenotypic evolution using multivariate quantitative genetics. Molecular Ecology, 15: 883-896.
- Navarro N, Klingenberg CP (2007) Mapping multiple QTLs of geometric shape of the mouse mandible, in S. Barber, P.D. Baxter and K.V. Mardia (eds), Systems Biology and Statistical Bioinformatics, p. 125-128. Leeds, Leeds University Press.
- Klingenberg CP (2010) Evolution and development of shape: Integrating quantitative approaches. Nature Reviews Genetics, 11: 623-635.
- Martínez-Abadías N, Esparza M, Sjøvold T, González-José R, Santos M, Hernández M (2009) Heritability of human cranial dimensions: Comparing the evolvability of different cranial regions. Journal of Anatomy, 214: 19-35.
- Martínez-Abadías N, Esparza M, Sjøvold T, González-José R, Santos M, Hernández M, Klingenberg CP (2012) Pervasive genetic integration directs the evolution of human skull shape. Evolution, 66: 1010-23.
Classical books on Quantitative Genetics:
- Falconer DS and Mackay TFC (1996) Introduction to quantitative genetics, Essex: Longman Group, Ltd.
- Roff DA (1997) Evolutionary quantitative genetics, New York: Chapman & Hall.
- Lynch M and Walsh B (1998) Genetics analysis of quantitative traits, Sunderland, Massachusetts: Sinauer Associates.
Previous editions of this course
Former participants will have a 5 % discount on the Course Fee.
Furthermore, a 20 % discount on the Course Fee is offered for members of some organizations (Organizations with discount). If you want to apply to this discount please indicate it in the Registration form (proof will be asked later).
Spanish unemployed scientists, as well as Spanish PhD students without any grant or scholarship to develop their PhD, could benefit from a 40 % discount on the Course Fee. If you want to ask for this discount, please contact the course coordinators. That would apply for a maximum of 2 places and they will be covered by strict inscription order.
Discounts are not cumulative.
Thanks to the donations of former participants, this year there are scholarships available for PhD students. The scholarships are in the form of tuition fee waivers only, they do not cover travelling and lodging.